For professionals

Clinical applications

From the dental chair to the bronchoscope.

Ankaferd Blood Stopper® is approved in Türkiye for local use in dental and superficial bleeding⁠1. Published reports describe it in far more places than that, mostly in small studies. This atlas keeps the two apart.

Approved indication · Türkiye
Local application in dental and superficial bleeding, approved by the Turkish Ministry of Health⁠1.
Reported in the literature only
Described in publications, mostly small studies and case series. Not an approved indication.

In the EU, Ankaferd Blood Stopper® is a CE-marked medical device (Class III, Directive 93/42/EEC, notified body TSE) for the topical control of external bleeding, and is distributed in Germany. Status in other regions is still being confirmed.

Explore the six areas Open the evidence library
Atlas of clinical areas Anatomical line drawing of a human figure seen from the front, with six numbered markers: the mouth for dental use, the nose for ENT, the stomach for GI endoscopy, the lungs for pulmonology, the neck, heart, kidney and pelvis for surgery, and the forearm for wound care. Dental and wound markers are solid, showing the approved indication in Türkiye (dental and superficial bleeding); the other four are dashed, showing areas reported in the literature only.
Fig. 1Where Ankaferd has been studied or used. Solid markers: the approved indication in Türkiye (dental and superficial bleeding only). Dashed: reported in the literature only. Illustrative, not to scale.
Evidence library
Fig. 2a applied solution b empty extraction socket filled by clot c gingival margin d alveolar bone Illustrative, not to scale.

01 / 06DentalDental bleeding · approved (TR)

The dental chair.

Local application in dental bleeding is approved by the Turkish Ministry of Health⁠1. The procedures and patient groups below come from published reports⁠2; they are not separate indications.

What has been studied

Approved indication · Türkiye

  • Local application in dental bleeding

Published reports · not separate indications

  • Post-extraction bleedingProcedure
  • Patients on anticoagulantsPopulation
  • Haemophilia & von Willebrand diseasePopulation
  • Periodontal surgeryProcedure
  • PulpotomyProcedure

Evidence

Study designs for this area: to be mapped from the evidence library.

Dental studies in the evidence library

Fig. 3a anterior nasal septum b adenoid, posterior nasopharyngeal wall c palatine tonsil Illustrative, not to scale.

02 / 06ENTReported in literature only

Ear, nose & throat.

Reports describe topical use in three ENT settings⁠1⁠2. None of them is part of the approved indication.

What has been studied

Reported in the literature

  • AdenoidectomyProcedure
  • TonsillectomyProcedure
  • Anterior epistaxisBleeding source

Evidence

Study designs for this area: to be mapped from the evidence library.

ENT studies in the evidence library

Fig. 4a endoscope b ulcer bed with forming clot c gastric folds Illustrative, not to scale.

03 / 06GI endoscopyReported in literature only

Through the endoscope.

In endoscopy it has been reported as a topical option across several sources of gastrointestinal bleeding⁠1⁠2.

What has been studied

Reported in the literature

  • Peptic ulcer bleedingUpper GI
  • Variceal bleedingUpper GI
  • Non-variceal bleedingUpper GI
  • Rectal ulcerLower GI
  • GI tumour bleedingOncology

Evidence

Study designs for this area: to be mapped from the evidence library.

Endoscopy studies in the evidence library

Fig. 5a thyroid bed after lobectomy b trachea c recurrent laryngeal nerve, behind the bed d thyroid cartilage Dashed lines: keep-clear margin around the nerve. One of six surgical settings, chosen to show the caution. Illustrative, not to scale.

04 / 06SurgeryReported in literature only

In the operating theatre.

Surgical reports span six quite different procedures, from the neck to the perineum⁠1⁠2. Each is a small body of evidence on its own.

What has been studied

Reported in the literature

  • ThyroidectomyNeck
  • Coronary artery bypass graftingCardiac
  • Percutaneous nephrolithotomyUrology
  • ProstatectomyUrology
  • EpisiotomyObstetrics
  • Cutaneous incisionsSkin

Keep it off exposed nervesPotential neurotoxicity has been seen in rodents, and its relevance after direct nerve exposure is debated⁠1. Avoid direct application on exposed neural tissue and follow the Instructions for Use: IFU wording to be confirmed.

Evidence

Study designs for this area: to be mapped from the evidence library.

Surgical studies in the evidence library

Fig. 6a bronchoscope b segmental bronchus, bleeding source c instilled solution Illustrative, not to scale.

05 / 06PulmonologyReported in literature only

Into the airways.

Endobronchial instillation has been described for haemoptysis in one retrospective series. It is the thinnest evidence on this page, so we show it as exactly that.

What has been studied

Reported in the literature

  • Haemoptysis Endobronchial instillation via bronchoscopeRetrospective

20

patients with haemoptysis, endobronchial instillation⁠3⁠4

Retrospective series · Uzun et al. 2013

1

series. One retrospective report generates hypotheses; it cannot confirm benefit.

Controlled trials called for

Evidence

A single retrospective series of 20 patients⁠3⁠4. No controlled data are cited here.

Pulmonology studies in the evidence library

Fig. 7a epidermis b dermis with capillary loops c subcutis d superficial bleed Illustrative, not to scale.

06 / 06Wound & first aidSuperficial bleeding · approved (TR)

Wounds & first aid.

The approval in Türkiye covers superficial bleeding⁠1. Effects on wound healing and infection are not approved claims and remain investigational.

What has been studied

Approved indication · Türkiye

  • Local application in superficial bleeding

Reported use

  • External bleeding in Turkish hospitals & ambulances⁠5 Primary source to followReported use

Investigational · not established

  • Wound healing
  • Antimicrobial activity
  • Antineoplastic activity

Evidence

Effects beyond bleeding control must be regarded as investigational⁠1. Study designs for this area: to be mapped from the evidence library.

Wound and first-aid studies in the evidence library

Reading this page

What this atlas does not say.

Six areas, two very different kinds of status. These are the limits that apply to all of them.

  1. It is not a list of indications.

    The approved indication is local application in dental and superficial bleeding, in Türkiye⁠1. ENT, endoscopy, surgery and pulmonology are reported in the literature only. In the EU it is CE-marked for the topical control of external bleeding and distributed in Germany; status in other regions is still being confirmed.

  2. The numbers are small.

    Much of the evidence is in vitro, animal and small clinical work; the clinical literature is mostly small studies and case series. Reviewers call for controlled trials⁠1⁠2. Animal work includes a swine bleeding model from Ankara University⁠6; its exact setting is to be confirmed.

  3. Some effects are investigational.

    Wound-healing, antimicrobial and antineoplastic effects must be regarded as investigational⁠1.

  4. Avoid exposed neural tissue.

    Biocompatible in most studies, with potential neurotoxicity seen in rodents⁠1. Always follow the Instructions for Use.

For healthcare professionals

Working in one of these fields?

Ask the team about application in your setting, the Instructions for Use, or the studies behind each area.

Contact the team Open the evidence library
References on this page (6)
  1. [1]Tibi SE, et al. Beyond hemostasis: a narrative review on the multifaceted therapeutic potential of Ankaferd Blood Stopper. Ann Med Surg. 2025/26;88(1):522–533. doi:10.1097/MS9.0000000000004388
  2. [2]Çiftçiler R, Haznedaroğlu İC. Ankaferd hemostat: from molecules to medicine. Turk J Med Sci. 2020;50(7):1739–1750. doi:10.3906/sag-1908-161
  3. [3]Simsek C, Selek S, Koca M, Haznedaroglu IC. Proteomic and transcriptomic analyses to explain the pleiotropic effects of Ankaferd blood stopper. SAGE Open Med. 2017;5:2050312117722569. doi:10.1177/2050312117722569
  4. [4]Uzun et al. 2013. Endobronchial Ankaferd Blood Stopper for haemoptysis, n = 20, as summarised in Simsek et al. 2017. Details to be confirmed.
  5. [5]Wikipedia contributors. “Ankaferd Blood Stopper.” Wikipedia, The Free Encyclopedia. Encyclopaedic secondary source, used here for history and status only.
  6. [6]Hemostatic efficacy of Ankaferd Blood Stopper in a swine bleeding model (Ankara University). Bibliographic details to be confirmed.